Control of spiral wave in two-dimensional FitzHugh-Nagumo equation is studied. The phase space compression approach is used to confine the system trajectory into a finite area and to annihilate spiral wave in the numerical simulation. Three stages are found in the control process. The spiral is driven to a homogenous stationary state when the compress limit is small; the spiral is stable with a fixed frequency when the compression limit is large; in the intermediate controlling parameter regime, the spatiotemporal turbulent state is observed. The controlling process is investigated by considering system pattern, variable evolution, phase space trajectory, etc, and the characteristics of amplitude function and oscillatory frequency are summarized as well.