This study employs semi-classical quantum molecular dynamics to investigate the influence of high momentum distribution on nuclear reaction systems, using photons produced by nucleon bremsstrahlung as indicators. The research examines the relationship between this influence and the incident energy, collision parameters, and the differences in isotopic spin cross-sections. Under the condition of a 20% high-momentum distribution and with nuclear energy conservation ensured, a system distinct from conventional configurations is constructed by sampling neutrons and protons via the Monte Carlo method, with the selected nucleons exhibiting characteristics of high-momentum nucleons. The effects of high-momentum distributions within nuclei on bremsstrahlung photons are analyzed through results of heavy-ion collisions across nuclear systems spanning light to heavy species. The results indicate that for the collision systems studied, at an incident energy of 50 MeV/u, for nuclear systems of varying masses—ranging from the light-mass system (¹⁸O+¹⁸O), the lower-mass system (⁴⁶Ca+⁴⁶Ca), the medium-mass system (⁸⁶Kr+⁸⁶Sr), to the heavy-mass system (¹²⁴Sn+¹²⁴Sn) exhibit higher photon densities in the high-energy region for high momentum distribution systems compared to conventional systems, while the photon density in the low-energy region shows no significant difference. At a collision parameter b=0 fm, the energy shift phenomenon of photons produced by collisions becomes more pronounced with increasing incident energy, peaking at E=150 MeV/u. This energy shift phenomenon induced by high momentum distribution is generally present across collision parameters ranging from b=0 fm to b=6 fm. When considering isotopic spin cross-sections, high momentum distribution affects the collision probability of the system. Therefore, high momentum distribution has a significant impact on nuclear reaction systems, closely related to incident energy and isotopic spin cross-sections.