HU Xiaochuan; ZHANG Yimiao; JIN Xinrui; XING Renfang; ZHANG Rui

doi:10.7498/aps.74.20250080

Abstract

Cold atmospheric plasma (CAP) is considered to be a highly promising cancer treatment method, due to its “selective” anti-cancer effect. However, the physical theoretical explanation about this effect and the microscopic interactive mechanisms between CAP and tumors are still lacking. In this work, the CAP-induced electric field-caused electroporation (EP) processes of the cell membrane are modeled based on molecular dynamics. Additionally, the umbrella sampling method is utilized to compute the free energy profile of the intracellular permeation processes of the reactive oxygen species (ROS) through EP-formed pore-like structures at different EP stages. Comparative results are shown as follows. 1) Cancer cell membranes with lower cholesterol components show lower EP-generation threshold and faster EP-formation, and 2) lower free-energy barrier and earlier occurrence of free-energy barrier reduction are shown in all EP stages in cancer cell membrane. The above results explain the difference between cancer cells and normal cells when affected by CAP. Our work delves into the formation of CAP-induced EP and the transport of ROS through EP-formed pore-like structures, which contributes to a better understanding of the microscopic mechanisms of the “selective” anti-cancer effect of CAP, and provides important references for developing CAP-based cancer treatment methods, and devices, thereby facilitating the translation of CAP into clinical applications.

Keywords:

Authors and contacts

Corresponding author: ZHANG Rui, pczhangrui@163.com

Funds: Project supported by the Key Research and Development Program of Shaanxi Province, China (Grant No. 2024SF-YBXM-386) and the Natural Science Basic Research Program of Shaanxi Province, China (Grant No. 2023-JC-YB-004).

FullText HTML

References

[1]
[2]
[3]
[4]
[5]
[6]
[7]
[8]
[9]
[10]
[11]
[12]
[13]
[14]
[15]
[16]
[17]
[18]
[19]
[20]
[21]
[22]
[23]
[24]
[25]
[26]
[27]
[28]
[29]
[30]
[31]
[32]
[33]
[34]
[35]
[36]
[37]
[38]
[39]
[40]
[41]
[42]
[43]
[44]
[45]
[46]
[47]
[48]
[49]

Cited By

DownLoad: Full-Size Img PowerPoint

DownLoad: Full-Size Img PowerPoint

DownLoad: Full-Size Img PowerPoint

DownLoad: Full-Size Img PowerPoint

DownLoad: Full-Size Img PowerPoint

DownLoad: Full-Size Img PowerPoint

DownLoad: Full-Size Img PowerPoint

DownLoad: Full-Size Img PowerPoint

DownLoad: Full-Size Img PowerPoint

DownLoad: Full-Size Img PowerPoint

序号 POPC数量胆固醇数量胆固醇含量/% 水分子数 X/nm Y/nm Z/nm

模型1 128 0 0 4873 6.03 6.03 9.07
模型2 112 16 12.5 4705 5.94 5.94 8.25
模型3 102 26 20.3 4513 5.78 5.78 8.39

DownLoad: CSV

[1]
[2]
[3]
[4]
[5]
[6]
[7]
[8]
[9]
[10]
[11]
[12]
[13]
[14]
[15]
[16]
[17]
[18]
[19]
[20]
[21]
[22]
[23]
[24]
[25]
[26]
[27]
[28]
[29]
[30]
[31]
[32]
[33]
[34]
[35]
[36]
[37]
[38]
[39]
[40]
[41]
[42]
[43]
[44]
[45]
[46]
[47]
[48]
[49]

[1]	Xing Ren-Fang, Chen Ming, Li Rui-Yu, Li Shu-Qian, Zhang Rui, Hu Xiao-Chuan. Effect of alternating electric field induced by cold atmospheric plasma on conformation and function of interleukin-6. Acta Physica Sinica, 2024, 73(18): 188703. doi: 10.7498/aps.73.20240927
[2]	Zhang Hong, Guo Hong-Xia, Pan Xiao-Yu, Lei Zhi-Feng, Zhang Feng-Qi, Gu Zhao-Qiao, Liu Yi-Tian, Ju An-An, Ouyang Xiao-Ping. Transport process and energy loss of heavy ions in silicon carbide. Acta Physica Sinica, 2021, 70(16): 162401. doi: 10.7498/aps.70.20210503
[3]	Zhu Qi, Wang Sheng-Tao, Zhao Fu-Qi, Pan Hao. Effect of stacking fault tetrahedron on spallation of irradiated Cu via molecular dynamics study. Acta Physica Sinica, 2020, 69(3): 036201. doi: 10.7498/aps.69.20191425
[4]	Yin Yue-Hong, Xu Hong-Ping. Theoretical study on the hydrogen storage properties of (MgO)₄ under external electric field. Acta Physica Sinica, 2019, 68(16): 163601. doi: 10.7498/aps.68.20190544
[5]	Deng Yong-He, Wen Da-Dong, Peng Chao, Wei Yan-Ding, Zhao Rui, Peng Ping. Heredity of icosahedrons: a kinetic parameter related to glass-forming abilities of rapidly solidified Cu56Zr44 alloys. Acta Physica Sinica, 2016, 65(6): 066401. doi: 10.7498/aps.65.066401
[6]	Liu Jun-Juan, Wei Zeng-Jiang, Chang Hong, Zhang Ya-Lin, Di Bing. Dynamics of polarons in organic conjugated polymers with impurity ions. Acta Physica Sinica, 2016, 65(6): 067202. doi: 10.7498/aps.65.067202
[7]	Yin Yue-Hong, Chen Hong-Shan, Song Yan. The electric field effect on the hydrogen storage of (MgO)12 by ab intio calculations. Acta Physica Sinica, 2015, 64(19): 193601. doi: 10.7498/aps.64.193601
[8]	Yang Cheng-Bing, Xie Hui, Liu Chao. Molecular dynamics simulation of average velocity of lithium iron across the end of carbon nanotube. Acta Physica Sinica, 2014, 63(20): 200508. doi: 10.7498/aps.63.200508
[9]	Ling Zhi-Gang, Tang Yan-Lin, Li Tao, Li Yu-Peng, Wei Xiao-Nan. Molecular structure and properties of zirconiumdioxide under the external electric field. Acta Physica Sinica, 2014, 63(2): 023102. doi: 10.7498/aps.63.023102
[10]	Wang Jian-Wei, Song Yi-Xu, Ren Tian-Ling, Li Jin-Chun, Chu Guo-Liang. Molecular dynamics simulation of Lag effect in fluorine plasma etching Si. Acta Physica Sinica, 2013, 62(24): 245202. doi: 10.7498/aps.62.245202
[11]	Ling Zhi-Gang, Tang Yan-Lin, Li Tao, Li Yu-Peng, Wei Xiao-Nan. Molecular structure and electronic spectrum of 2, 2, 5, 5-tetrachlorobiphenyl under the extenal electric field. Acta Physica Sinica, 2013, 62(22): 223102. doi: 10.7498/aps.62.223102
[12]	Gao Yan, Chen Rui-Yun, Wu Rui-Xiang, Zhang Guo-Feng, Xiao Lian-Tuan, Jia Suo-Tang. Electric field induced polarization dynamics of graphene oxide. Acta Physica Sinica, 2013, 62(23): 233601. doi: 10.7498/aps.62.233601
[13]	Zuo Ying-Hong, Wang Jian-Guo, Zhu Jin-Hui, Niu Sheng-Li, Fan Ru-Yu. Investigation of the cathode electric field at the initial stage of explosive electron emission. Acta Physica Sinica, 2012, 61(17): 177901. doi: 10.7498/aps.61.177901
[14]	Shen Zhuang-Zhi, Wu Sheng-Ju. Dynamic behavior of a cavitation bubble in acoustic field and electric field. Acta Physica Sinica, 2012, 61(12): 124301. doi: 10.7498/aps.61.124301
[15]	Fan Qin-Na, Li Wei, Zhang Lin. Molecular dynamics study of relaxation and local structure changes in a rapidly quenched molten Cu57 cluster. Acta Physica Sinica, 2010, 59(4): 2428-2433. doi: 10.7498/aps.59.2428
[16]	Qin Xiao-Gang, He De-Yan, Wang Ji. Geant 4-based calculation of electric field in deep dielectric charging. Acta Physica Sinica, 2009, 58(1): 684-689. doi: 10.7498/aps.58.684
[17]	Chen Min, Wang Jun, Hou Qing. Influence of helium on volume change and stability of titanium structure: An atomistic simulation. Acta Physica Sinica, 2009, 58(2): 1149-1153. doi: 10.7498/aps.58.1149
[18]	Ruan Wen, Luo Wen-Lang, Zhang Li, Zhu Zheng-He. Molecular structure and electronic spectrum of styrene under the external electric field. Acta Physica Sinica, 2008, 57(10): 6207-6212. doi: 10.7498/aps.57.6207
[19]	Deng Chuang, Weng Yu-Min, Xu Zhi-Zhong, Fei Lun. Properties of solitons stimulated by electric field in collagen molecule. Acta Physica Sinica, 2005, 54(5): 2429-2434. doi: 10.7498/aps.54.2429
[20]	Zhang Lin, Wang Shao-Qing, Ye Heng-Qiang. Molecular dynamics study of the structure changes in a high-angle Cu grain boundary by heating and quenching. Acta Physica Sinica, 2004, 53(8): 2497-2502. doi: 10.7498/aps.53.2497

Catalog

Vol. 74, Issue 11 - 2025-06-05

Metrics

Abstract views: 428
PDF Downloads: 22
Cited By: 0

姓名
邮箱
手机号码
标题
留言内容
验证码

Search

Article

留言板

Abstract

Authors and contacts

Corresponding author: ZHANG Rui, pczhangrui@163.com

FullText HTML

References

Cited By

Catalog

Metrics

Authors

Referees

About Journal

About

序号	POPC数量	胆固醇数量	胆固醇含量/%	水分子数	X/nm	Y/nm	Z/nm
模型1	128	0	0	4873	6.03	6.03	9.07
模型2	112	16	12.5	4705	5.94	5.94	8.25
模型3	102	26	20.3	4513	5.78	5.78	8.39

Search

Article

留言板

Abstract

Authors and contacts

Corresponding author: ZHANG Rui, pczhangrui@163.com

FullText HTML

References

Cited By

Catalog

Metrics

Publishing process

Authors

Referees

About Journal

About